Short answer: Cushing’s disease (hyperadrenocorticism) is excess cortisol production – usually from a benign pituitary tumor (85%) or an adrenal tumor (15%). Signs: increased thirst/urination/appetite, pot belly, hair loss, thin skin, panting. Treated with trilostane (Vetoryl).
What you should actually do
- 85% pituitary-dependent (PDH), 15% adrenal-dependent (ADH).
- Classic signs: PU/PD, polyphagia, abdominal distension, hair loss, thin skin, calcinosis cutis.
- Diagnosis: LDDS test (low-dose dexamethasone suppression) or ACTH stim, plus abdominal ultrasound.
- Treatment: trilostane (Vetoryl) for both forms; mitotane (Lysodren) alternative.
- Lifespan after diagnosis: typically 2-3 years with treatment.
Cushing’s is one of the most common endocrine diseases in older dogs (Poodles, Dachshunds, small terriers, Boxers over-represented). It often presents as a slow progression rather than acute illness.
Untreated Cushing’s shortens life and decreases quality of life. With trilostane, ACTH stim monitoring every 3 months, and good owner compliance, dogs do well for years.
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⚕️ Medical Disclaimer
The information on this page is intended for educational purposes only and does not replace a hands-on veterinary examination. Drug doses depend on your dog’s complete clinical picture, concurrent medications, and the exact product formulation. Always confirm dosing with your veterinarian before administering any medication, and contact a 24-hour veterinary emergency service or animal poison control immediately if you suspect a medication overdose or adverse reaction. Editorial standards: every drug dose published on PuppaDogs is cross-checked against multiple authoritative veterinary references and reviewed by PuppaDogs Veterinary Editorial Team before publication.
